Each coaled tablet contains: Vitamin B1 (Thiamine): 100 mg, Vitamin B6 (Pyridoxine): 200 mg, Vitamin B12 (Cyanocobalamine): 200 mcg.
List of Ingredients: Thiamine Mononitrate, Pyridoxine Hydrochloride, Cyanocobalamine.
Excipients/Inactive Ingredients: Croscarmellose Sodium, Magnesium Stearate, Cellactose, Hydroxypropyl Cellulose and Opadry Pink.
Pharmacology: Mechanism of Action: Axcel Vitalic Tablets consists of three essential neurotropic vitamins which are vitamins B1, B6 and B12 in high dosage. These three vitamins are important for the metabolism in the peripheral and central nervous system.
In various investigations, their effect on the regeneration of nerves has been shown using the vitamins individually and in combination. Vitamin B1 has a vital role in major metabolic processes. Vitamin B6 has an analgesic effect. Vitamin B12 helps in the formation of blood cell and prevents degenerative processes of the nervous system. The individual function and the beneficial biochemical links between these three vitamins justify their combined use.
Pharmacokinetics: Vitamin B1 is absorbed from the gastrointestinal tract. It is widely distributed to most of body tissues. Vitamin B1 and its metabolites are excreted in the urine when the amounts excess the body's requirement.
Vitamin B6 is well absorbed from the gastrointestinal tract. It is then followed by the hydrolysis of its phosphorylated derivatives to pyridoxal phosphate. The primary form of pyridoxal phosphate crosses the cell membranes. The metabolite, 4-pyridoxic acid is excreted in the urine.
Vitamin 12 is bound to intrinsic factor in the presence of gastric acid and pancreatic proteases. Then, it is actively absorbed from the gastrointestinal tract. Around 90% of Vitamin B12 is stored in the liver. Vitamin B12 is mostly excreted in the bile.
Axcel Vitalic Tablets is indicated for neurological and other disorders associated with disturbance of metabolic functions influenced by B complex vitamins, including diabetic polyneuropathy, alcoholic peripheral neuritis and post influenza neuropathies.
Axcel Vitalic Tablets is also recommended for the treatment of neuritis and neuralgia of the spinal nerves, especially facial paresis, cervical syndrome, low back pain, ischialgia.
1 tablet 3 times daily for moderate cases and follow-up therapy for a course of injections.
It is taken with or after meal by swallowing with a little liquid without chewing.
The duration of the treatment is determined by the doctor.
Prolonged overdose of vitamin B6 (i.e. for longer than 2 months and more than 1 g per day) may cause neurotoxic effects.
Contraindicated in patients hypersensitive to any of the active ingredients of the product, and children due to high content of active ingredients.
Use in Pregnancy & Lactation: No risks have become known during pregnancy when taken at the recommended dosage. Vitamins B1, B6 and B12 are distributed into breast milk, but the risks of overdose for the infant are not known. In individual cases, high doses of Vitamin B6 (i.e. >600 mg daily) may inhibit the breast milk production.
No risks have become known during pregnancy when taken at the recommended dosage. Vitamins B1, B6 and B12 are distributed into breast milk, but the risks of overdose for the infant are not known. In individual cases, high doses of Vitamin B6 (i.e. >600 mg daily) may inhibit the breast milk production.
Hypersensitivity reactions such as sweating, tachycardia (rapid heartbeat) and skin reactions with itching and urticaria have occurred very rarely.
Inform the doctor if the previously mentioned symptoms or other unwanted effects occur.
Vitamin B6 reduces the effects of L-dopa when taken concurrently.
Store below 30°C. Protect from light.
A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.
Axcel Vitalic FC tab
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